Combined Effects of Simvastatin and Enamel Matrix Derivative on Odontoblastic Differentiation of Human Dental Pulp Cells
نویسندگان
چکیده
منابع مشابه
Histological Effects of Enamel Matrix Derivative on Exposed Dental Pulp.
INTRODUCTION Direct pulp capping procedure is a therapeutic application of a drug on exposed tooth pulp in order to ensure the closure of the pulp chamber and to allow the healing process to take place. OBJECTIVE The aim of this study was to examine the histological effects of Emdogain® on exposed tooth pulp of a Vietnamese pig (Sus scrofa verus). METHODS The study comprised 20 teeth of a V...
متن کاملEffects of leukemia inhibitory factor on proliferation and odontoblastic differentiation of human dental pulp cells.
INTRODUCTION The purpose of this study was to determine whether the leukemia inhibitory factor (LIF) is expressed in human dental tissue and exerts its effect on proliferation and odontoblastic differentiation of the dental pulp cells (DPCs). METHODS An immunohistochemical assay was used to detect the expression of LIF and leukemia inhibitory factor receptor (LIFR) in the human dental pulp. T...
متن کاملLipopolysaccharide stimulation improves the odontoblastic differentiation of human dental pulp cells.
Lipopolysaccharide (LPS) is one of the causative agents of pulpitis and previous studies have demonstrated that the LPS stimulation of human aortic valve interstitial cells induces inflammatory mediators and the gene expression of osteogenic factors. Therefore, in the present study, it was hypothesized that LPS affects the odontoblastic differentiation of human dental pulp cells (hDPCs). In ord...
متن کاملChanges in SIRT gene expression during odontoblastic differentiation of human dental pulp cells
OBJECTIVES The aim of this study was to investigate the expression of 7 different sirtuin genes (SIRT1-SIRT7) in human dental pulp cells (HDPCs), and to determine the role of SIRTs in the odontoblastic differentiation potential of HDPCs. MATERIALS AND METHODS HDPCs were isolated from freshly extracted third molar teeth of healthy patients and cultulred in odontoblastic differentiation inducin...
متن کاملIn vitro assessment of alendronate toxic and apoptotic effects on human dental pulp stem cells
Objective(s): Osteonecrosis of the jaw, as an exposed necrotic bone in the oral cavity, is one of the adverse effects of bisphosphonates, which have an affinity for bone minerals. This study investigates the cytotoxic effects of alendronate (ALN) as a nitrogen-containing bisphosphonate, on human dental pulp stem cells (hDPSCs). Materials and Methods: The mesenchymal stem cells (MSCs), obtained ...
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ژورنال
عنوان ژورنال: Journal of Endodontics
سال: 2013
ISSN: 0099-2399
DOI: 10.1016/j.joen.2012.10.013